On a cruise to Hawaii, an unconscious man floating in a small dinghy is taken aboard the MS Discovery III.
Shortly after he died on the infirmary, strange murders happen on board and people panic when the ship's doctor discovers a strange virus that he tries to keep secret as it spreads.
When the captain of the ship is not granted a landing permit for Hawaii, the leftover passengers despair and try to survive until the promised help of the CDC arrives. A race against time and death begins.
The journalist Victoria has her doubts about a salvation and reveals a gruesome mystery that affects her as well and questions her entire past and future life.